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Hierarchical Assembly of Fluorescent Materials

Hierarchical Assembly of Fluorescent Materials

Fluorescent Small-Molecule Ionic, Isolation Lattices (SMILES)

We discovered the brightest fluorescent materials and are exploring the underlying design rules to make optical and photonic materials. These materials are called small-molecule, ionic isolations lattices or SMILES for short. Some of our goals are to address scientific challenges around the hierarchical assembly of different molecular fluorophores into photonic materials and how the resulting packing and doping in nanoparticles and crystals can be used to understand and control the flow of excitons to productive sites for light emission and photon upconversion in solids. This approach lays the foundation for versatile, ‘plug-and-play’ photonic materials for communications, solar, display, and new quantum technologies. The start-up stemming from these materials, Halophore, stands ready to assist with commercialization.

These materials are being explored in collaboration Krishnan Raghavachari (Indiana University), Bo Laursen (University of Copenhagen, Denmark), Jerome Lacour (University of Geneva, Switzerland), Bo Albinsson (Chalmers University, Sweden), Grace Han (UC Santa Barbara), Vinod Menon (CUNY), Matt Sfeir (GaTech), Keisuje Goda (Tokyo University, Japan) and Junsheng Chen (University of Copenhagen, Denmark).

References

194. Chen, J.; Juhl, K.; Zhang, F.; He, Y.; Flood, A. H.; Kjaer, A.; Laursen B. W., NIR: Near-Infrared Emitting Organic Nanoparticles Based on Small-Molecule Ionic Isolation Lattices for in-vivo Imaging of Human Brain Cancer, ACS Appl. Nano Mater. 2025, 8, 41, 19739-19747

192. Olsson, A. H.; Tripathy, V.; Yamamoto, N.; Usuba, J.; Leavitt, J. S.; Kambas, E. A.; VanDenburgh, K. L.; Raghavachari, K.; Laursen, B. W.; Han, G. G. D.; Flood, A. H. Bambusuril Small-Molecule Ionic Isolation Lattices using Crystal Engineering, J. Am. Chem. Soc., 2025 accepted

185. Loveless, M. K.; Che, M.; Sanchez, A. J.; Tripathy, V.; Laursen, B. W.; Pamidighantam, S.; Raghavachari, K.; Flood, A. H., Extracting Recalcitrant Redox Data on Fluorophores to Pair with Optical Data for Predicting Small-Molecule, Ionic Isolation Lattices, Digital Discovery, 2024, 3, 2105-2117.

182. Stenspil, S. G.; Olsson, A. H.; Mucci, R.; Pink, M.; Besnard, C.; Lacour, J.; Flood, A. H.; Laursen, B. W., Supramolecular Control of Helicene CPL Emitters in Molecular Solids and Bright Nanoparticles, Angew. Chem. Int. Ed. 2024, 63, e202412320

179. Tripathy, V.; Flood, A. H.; Raghavachari, K., Accelerated computer-aided screening of optical materials: Investigating the potential of ∆-SCF Methods to predict emission maxima of large dye molecules, J. Phys. Chem. A., 2024, 128, 8333-8345

178. Yadav, R. K.; Satapathy, S.; Deshmukh, P.; Datta, B.; Sharma, A.; Olsson, A. H.; Chen, J.; Laursen, B. W.; Flood, A. H.; Sfeir, M. Y.; Menon V. M., Direct Writing of Room Temperature Polariton Condensate Lattice Nano Letters, 2024, 24, 4945-4950.

176. Stenspil, S. G.; Chen, J.; Liisberg, M. B.; Flood, A. H.; Laursen, B. W., Control of the fluorescence lifetime in dye based nanoparticles, Chem. Sci. 2024, 15, 5531-5538.

175. Deshmukh, P.; Satapathy, S.; Michail, E.; Olsson, A. H.; Bushati, R.; Yadav, R. K.; Khatonair, M.; Chen, J.; John, G.; Laursen, B. W.; Flood, A. H.; Sfeir, M. Y.; Menon, V. M., A plug-and-play molecular approach for room temperature polariton condensation, ACS Photonics, 2024, 11, 348-355

170. Nishiyama,R. Furuya, K.; McCann, P.;Kacenauskaite, L.; Laursen, B. W.; Flood, A. H.; Hiramatsu, K.; Goda, K. Boosting the Brightness of Raman Tags Using Cyanostar Macrocycles, Anal. Chem. 2023, 95, 12835-12841. https://doi.org/10.1021/acs.analchem.3c01958

168. Edhborg, F.; Olesund, A.; Tripathy, V.; Wang, Y.; Sadhukhan, T.; Olsson, A. H.; Bisballe, N.; Raghavachari, K.; Laursen, B. W.; Albinsson, B.; Flood, A. H., Triplet States of Cyanostar and its Anion Complexes, J. Phys. Chem. A, 2023, 127, 5841-5850. https://doi.org/10.1021/acs.jpca.3c02701

165. Kacenauskaite, L.; Olsson, A. H.; Flood, A. H.; Laursen, B. W., Universal Concept for Bright, Organic, Solid-State Emitters-Doping of Small-Molecule Ionic Isolation Lattices with FRET, J. Am. Chem Soc. 2022, 144, 19981-19989. https://doi.org/10.1021/jacs.2c08540

163. Chen, J.; Stenspil, S. G.; Kaziannis, S.; Kacenauskaite, L.; Lenngren, N.; Kloz, M.; Flood, A. H.; Laursen, B. W., Quantitative Energy Transfer in Organic Nanoparticles Based on Small-Molecule Ionic Isolation Lattices for UV Light Harvesting, ACS Appl. Nano Mater. 2022, 5, 13887-13893. https://doi.org/10.1021/acsanm.2c01899

153. Chen, J.;Ali Fateminia, S. M.; Kacenauskaite, L.;Bærentsen, N.;Stenspil, S. G.; Bredehoeft, J.; Martinez, K. L.;Flood, A. H.; Laursen, B. W., Ultra-Bright Fluorescent Organic Nanoparticles Based on Small-Molecule Ionic Isolation Lattices, Angew. Chem. Int. Ed., 2021, 60, 9450. Hot Paper

143. Benson, C. R.; Kacenauskaite, L.; VanDenburgh, K. L.; Zhao, W.; Qiao, B.; Sadhukhan, T.; Pink, M.; Chen, J.; Borgi, S.; Chen, C.; Davis, B. J.; Simon, Y. C.; Raghavachari, K.; Laursen, B. W.; Flood, A. H., Plug-and-play Optical Materials from Fluorescent Dyes and Macrocycles, Chem, 2020. 6, 1978-1997. DOI

117. Qiao, B.; Hirsch, B. E.; Lee, S.; Pink, M.; Chen, C.-H., Laursen, B. W.; Flood, A. H., Ion-Pair Oligomerization of Chromogenic Triangulenium Cations with Cyanostar-modified Anions That Controls Emission in Hierarchical Materials. J. Am. Chem. Soc. 2017, 139, 6226-6233. DOI

Hierarchical Assembly of Fluorescent Materials

Fluorescent Small-Molecule Ionic, Isolation Lattices (SMILES)

References

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